Transfusion-induced immunomodulation and infection
نویسندگان
چکیده
منابع مشابه
Transfusion-induced immunomodulation and its possible role in cancer recurrence and perioperative bacterial infection.
Over the last decade, it has become evident that homologous transfusions carry immunologic consequences beyond the well-understood ones of alloimmunization to blood cell antigens. Transfusions constitute temporary transplants of large amounts of allogeneic antigen given intravenously and cause down-regulation of many cellular immune functions. These changes may explain in part the association o...
متن کاملDeleterious consequences of allogeneic blood transfusion on postoperative infection: really a transfusion-related immunomodulation effect?
The purported deleterious effect of transfusion-related immunomodulation (TRIM) on postoperative infection and its prevention by leukoreduction of transfused blood are a matter of great controversy among transfusion medicine specialists. In a recent review on this issue,1 Vamvakas and Blajchman pointed out that current evidence supporting a beneficial effect of leukoreduction is inconclusive be...
متن کاملDeleterious consequences of allogenic blood transfusion on postoperative infection: really a transfusion-related immunomodulation effect?
The purported deleterious effect of transfusion-related immunomodulation (TRIM) on postoperative infection and its prevention by leukoreduction of transfused blood are a matter of great controversy among transfusion medicine specialists. In a recent review on this issue,1 Vamvakas and Blajchman pointed out that current evidence supporting a beneficial effect of leukoreduction is inconclusive be...
متن کاملTransfusion-Associated Immunomodulation: Experimental Facts and Clinical Reality New Perspectives
Blood component transfusion may be required in association with emergency and chronic disease to improve hemodynamics and tissue oxygenation. Due to the risk of microbial transfection from donor to recipient, the blood is undergoing vigorous testing to improve safety. It is well known, however, that blood component transfusion may lead to certain acute side effects with a frequency of 0.5–2% de...
متن کاملTransfusion immunomodulation or TRIM: what does it mean clinically?
Evidence from a variety of sources indicate that allogeneic blood transfusions can induce clinically significant immunosuppression, as well as other effects, in recipients. This clinical syndrome is generally referred to in the Transfusion Medicine literature as transfusion-associated immunomodulation, or TRIM. TRIM has been linked to an improved clinical outcome in the setting of renal allogra...
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ژورنال
عنوان ژورنال: Transfusion
سال: 1991
ISSN: 0041-1132,1537-2995
DOI: 10.1046/j.1537-2995.1991.31391165165.x